A REVIEW ON SELF EMULSIFYING DRUG DELIVERY SYSTEMS
Abstract
The oral route is the preferred route for chronic drug therapy. Numerous potent lipophilic drugs exhibit low oral bioavailability due to their poor aqueous solubility properties (class II: low solubility and high permeability drugs).The most popular approach to increase the oral bioavailability of lipophilic drugs is the incorporation of the active lipophilic component into inert lipid vesicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes. Most lipid based formulations are designed to deliver the entire dose in solution thereby bypassing the dissolution process in the gastro-intestinal tract, which has been recognized as one of the main prerequisite for the efficiency of these formulations. These systems often lead to improvement in the therapeutics index of the lipophilic drugs through increased solubilization and modification of their pharmacokinetic profiles. The present article gives information regarding composition, mechanism, characterization and factors affecting the SEDDS.
Keywords
Self-emulsifying formulations, permeability, solubility, emulsions and therapeutic index.